Emi1 Class of Proteins Regulate Entry into Meiosis and the Meiosis I to Meiosis II Transition in Xenopus Oocytes
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چکیده
منابع مشابه
Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes.
Xenopus Aurora-A (also known as Eg2) is a member of the Aurora family of mitotic serine/threonine kinases. In Xenopus oocytes, Aurora-A phosphorylates and activates a cytoplasmic mRNA polyadenylation factor (CPEB) and therefore plays a pivotal role in MOS translation. However, hyperphosphorylation and activation of Aurora-A appear to be dependent on maturation-promoting factor (MPF) activation....
متن کاملThe Meiosis I-to-Meiosis II Transition in Mouse Oocytes Requires Separase Activity
Faithful segregation of homologous chromosomes during the first meiotic division is essential for further embryo development. The question at issue is whether the same mechanisms ensuring correct separation of sister chromatids in mitosis are at work during the first meiotic division. In mitosis, sister chromatids are linked by a cohesin complex holding them together until their disjunction at ...
متن کاملPlk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes
BACKGROUND Polo-like kinase 1 (Plk1), as a characteristic regulator in meiosis, organizes multiple biological events of cell division. Although Plk1 has been implicated in various functions in somatic cell mitotic processes, considerably less is known regarding its function during the transition from metaphase I (MI) to metaphase II (MII) stage in oocyte meiotic progression. METHODS In this s...
متن کاملCorrection: Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes
Copyright: © 2015 Riepsamen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملNicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes
Following exit from meiosis I, mammalian oocytes immediately enter meiosis II without an intervening interphase, accompanied by rapid reassembly of a bipolar spindle that maintains condensed chromosomes in a metaphase configuration (metaphase II arrest). Here we study the effect of nicotinamide (NAM), a non-competitive pan-sirtuin inhibitor, during meiotic maturation in mouse oocytes. Sirtuins ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2005
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.4.3.1532